BIO-SPICULE V2
Needle-free bio-microneedling on 99% TOP grade spicules. Five sets, one activator, one protocol.
CLEAR · FIRM · GLOW · BRIGHT · MELA
For clinics and aesthetic practitioners · Topical cosmetic, professional use
One technique, five goals.
| What it is | Peptology Labs, the four moves, the spicule itself | |
| Technology | 99% TOP: the three grades, the numbers, the SQT source | |
| Ours vs the market | Powder, microscope and cream, side by side | |
| Specification | The raw spicule as certified | |
| Certificates | Specification sheet and cosmetic filing | |
| Full ingredients | Every set and the activator, as filed | |
| The difference | How BIO-SPICULE compares, and the downtime | |
| Choose a set | Five sets at a glance, matched to the skin | |
| The five sets | CLEAR · FIRM · GLOW · BRIGHT · MELA, one page each | |
| Activator | Step 1B, the universal Part B | |
| Kit and packaging | What is in the box, storage | |
| Clinic protocol | Five steps, a visual guide | |
| Aftercare | Client care, and who should wait | |
| Clinic programme | Wholesale, sampler, training, private label, events | |
| Results | Before and after gallery | |
| Sources | Where every number comes from |
Reading the intensity dots. ●○○ gentlest, for first-timers and sensitive skin · ●●○ in between · ●●● stronger resurfacing.
A lab that tests, making skin products.
Peptology Labs in Carmona, Cavite runs a peptide testing service with a US laboratory partner, peptide synthesis and transdermal R&D. We bring the same habit to our own products: specification first, then the batch. PEPTICEUTICAL is our professional skin line; BIO-SPICULE V2 is its needle-free bio-microneedling system.
Needle-free bio-microneedling, in four moves.
Natural sponge spicules are tiny silica needles, finer than a hair. Massaged into the skin, millions of them open temporary micro-channels in the outer layer, so the actives that follow reach where a cream alone cannot. No needle, no device, no acid peel.
Channel
Massage drives the spicules into the outer layer, opening millions of micro-channels.
Deliver
The actives in the powder and activator, and the serum after, travel through them.
Stimulate
The skin reads the micro-channels as a signal to renew.
Renew
Spicules shed on their own in 2 to 3 days, taking dull surface cells with them.
99% TOP. Not all spicules are equal.
Sponge spicule powder is sold in three commercial grades. BIO-SPICULE V2 uses only the top one.
99% TOPIn BIO-SPICULE V2
99% First Class
70%
The same 99% TOP raw spicule as SQT. SQT's popular bio-microneedling runs on spicules from the same raw material source as BIO-SPICULE V2. Peptology is the regional distribution partner of this raw material, so your clinic gets brand-grade spicules first hand.
The spicule source
Brand names are trademarks of their owners and are named as customers of the spicule source, not as endorsers of BIO-SPICULE.
Side by side, the difference shows.
The same three checks on a typical market spicule and on our 99% TOP raw spicule.
Our 99% TOP raw spicule under the microscope
What it means at the chair: intact, even needles channel evenly on every pass, and a clean white powder keeps the paste and the finish clean.
The raw spicule, as certified.
| Parameter | Specification | Method |
|---|---|---|
| Source | Freshwater sponge, Spongilla fragilis; sponge body | — |
| Identification | positive | TLC |
| Sponge spicule content | not less than 99% | SJ/T 3328.4-2016 |
| Appearance | off white powder, characteristic odour | organoleptic |
| Particle size | 95% passing 100 to 180 mesh | mesh screen |
| Broken spicule rate | 5 to 10% (90 to 95% intact) | counting |
| Spicule count | 5 to 6 million per gram | dilution (manufacturer) |
| Loss on drying | less than 3% | GB/T 6284 |
| Loss on ignition | less than 10% | GB 25576-2020 |
| Lead · Arsenic · Cadmium · Mercury | ≤ 10 · ≤ 2 · ≤ 5 · ≤ 1 ppm | authorized lab |
| Total plate count | ≤ 1,000 cfu/g | plate count |
| Yeast and mould | ≤ 100 cfu/g | plate count |
| S. aureus, E. coli, Salmonella | negative | GB/T 7918.3 to .5 |
| GMO · BSE | free · free | — |
| Storage · shelf life | air-tight, dry and dark · three years sealed | — |
On paper, before it reaches you.
Raw spicule
Every lot of the 99% TOP raw spicule is released against this specification sheet: identity, spicule content, particle size, broken rate, heavy metals and microbes.
Finished product
Each of the five sets, powder plus activator, is filed as a domestic ordinary cosmetic with China's national cosmetic regulator (NMPA online filing system), made by a licensed cosmetic manufacturer.
Maker, filer and brand details on the source documents are withheld. Full filing records are shown to clinic partners on request.
| Set | Filed product (translated) | Filing no. | Filed |
|---|---|---|---|
| CLEAR | Green algae sponge skin renewal powder + hydra glow essence | 2026095••• | 2026-04-08 |
| FIRM | Blue diamond sponge skin renewal powder + hydra glow essence | 2026095••• | 2026-04-08 |
| GLOW | Pink "as new" skin renewal powder + hydra glow essence | 2026095••• | 2026-04-08 |
| BRIGHT | Pearl sponge skin renewal powder + hydra glow essence | 2026095••• | 2026-04-08 |
| MELA | Astragalus sponge skin renewal powder + hydra glow essence | 2026095••• | 2026-04-15 |
Filing type: domestic ordinary cosmetics (Guangdong online filing). First filing records dated 2026-04-15 (MELA 2026-04-22).
| Product name | Blue diamond sponge skin renewal powder + hydra glow beauty essence (brand withheld) |
| Filing number | Guangdong G cosmetic online filing 2026095••• (partly withheld) |
| Filing date | 2026-04-08 · first filing recorded 2026-04-15 |
| Filer · manufacturer | Licensed cosmetic manufacturers, production licences on file (names and addresses withheld) |
| Formula 1 · 2 | Powder · essence, on file |
| Also on record | Packaging artwork, executive standard, efficacy claims, label draft |
Every set, as filed.
Translated from the cosmetic filing records, in the order filed. Formula 1 is the powder (Step 1A); formula 2 is the activator (Step 1B), the same in every set.
Hydroxypropyl tetrahydropyrantriol is known as Pro-Xylane. Hydrolyzed sponge is the spicule.
Not just another bio-microneedling.
Grade
Top grade spicules, 90 to 95% of them intact, so every pass channels evenly.Fresh mix
The powder stays dry until it meets the activator at the chair: 1 to 1, mixed in 15 seconds.A real activator
Four forms of hyaluronic acid, two peptides, cica and oat beta-glucan. Zero acid, zero alcohol.Five goals
One technique, five sets. Match the set to the skin and the intensity to the client.| BIO-SPICULE | Needle microneedling | Chemical peel | |
|---|---|---|---|
| Needles | none, topical paste | yes | none |
| Acid | none in the activator | none | yes |
| Device | none, hands and brush | pen or roller | none |
Back to makeup by day three.
Why the effect lasts. In laboratory studies on sponge spicules, the micro-channels were numerous, about 850 per square millimetre, and closed only gradually over several days. Why the downtime stays low. No needle, so no open puncture wounds; the channels sit in the outer layer and the spicules leave on their own.
Match the set to the skin.
A simple way to start
- First session or sensitive skin: start with BRIGHT, then move up.
- Oily, congested skin: CLEAR.
- Tired, dull skin before an event: GLOW.
- Loss of bounce and visible pores: FIRM.
- Uneven tone and dark spots: MELA, with daily sunscreen.
Every set uses the same activator and the same five-step protocol. What changes is the actives in the powder and the intensity.
Universal Part B. Balancing activator elixir.
- 4D hyaluronic acid: four forms, from sodium hyaluronate to crosspolymer, for layered hydration.
- Oligopeptide-1 and Argireline (Acetyl Hexapeptide-1): two skin conditioning peptides.
- Cica and oat beta-glucan: soothing and comfort.
- Sclerotium gum: the glide for the massage.
- Base: water, glycerin, butylene glycol.
| Spec | As labelled |
|---|---|
| Fill | 5 mL |
| Use | Pour into Part A spicule powder and mix 15 s |
| Fits | CLEAR, FIRM, GLOW, BRIGHT and MELA |
Mix at the chair
One box, five treatments.
Illustration of the sampler box. Real photo to follow.
Single set box
Five treatments of one set, for the concern you see most.Mixed box
Any five powders across the five sets, with five activators.Sampler
One of every set, to match your clients before committing to full boxes.Storage and handling
- Store at 15 to 28 °C, sealed, away from sunlight.
- Mix only at the chair. Use a mixed bowl in the same session.
- Topical cosmetic for professional use. Not for injection, not for open wounds.
Private label boxes carry your clinic name on the vials and the box. Ask us for the artwork template.
Five steps, the same for every set.
Degrease
Cleanse and sanitise with a non-alcohol antiseptic wipe.
Mix
One powder plus one activator in the bowl. Brush until smooth.
15 sWork
Four quadrants, firm circles, pressure matched to set and skin.
7–15 minClean
Sponge off surface residue with cool distilled water.
Occlude
Chilled hyaluronic acid or collagen mask.
15–20 minBefore you start, check the aftercare page for anyone who should wait.
Let the skin shed on its own.
Who should wait or choose another treatment
- Open wounds, active infection or inflamed cystic lesions on the area
- Isotretinoin in the past 6 months
- Active eczema, rosacea flare or sunburn
- Pregnancy: ask your doctor first
Sunscreen protects the result. Daily sunscreen matters with every set, and most of all with MELA and GLOW, where the goal is a more even, brighter tone.
Grow your menu, without needles.
Wholesale boxes
Order by the box, one set or mixed freely across the five.Sampler
One pair of every set, to match your clients before you commit to full boxes.Training
Hands-on protocol training, and live demos at congresses and masterclasses.Private label
Your clinic name on our BIO-SPICULE V2 vials, made and labelled for you.How to start
Message us
Tell us your clinic, city and the skin concerns you see most.
Start with the sampler
Try all five sets on your own clients, with our protocol.
Order your sets
Full boxes of the sets your clients need, or your own label.
See it live
| Oct 28 | Global Scientific Congress, Davao |
| Oct 29 | Davao live demo masterclass, with a live BIO-SPICULE demo |
| Nov 29 | PhilbeautiQ ICON 2026, Quezon City |
Order · training · private label
+63 949 702 6016
WhatsApp, Viber or call · Mon to Sat, 9am to 6pm PHT
peptology.ph/bio-microneedling · Peptology Labs, Carmona, Cavite, Philippines
Before and after.
Real client photos, one pair per set, with consent on file. Every pair follows the same photo standard.
Photo standard. Written client consent · same light, angle and distance · no makeup or filter · note the set, number of sessions and days since the last session.
Where the numbers come from.
| Claim | Source |
|---|---|
| Source species, 99% spicule, mesh, broken rate, drying, ignition, heavy metals, microbes, shelf life | Raw spicule specification sheet, 99% TOP |
| Three grades; size; 5–6 million per gram; 5 to 68x; ~75% intact in market grades; 25 steps; QC and ISO | Spicule manufacturer data |
| Same raw material source as SQT; regional distribution | Peptology supply records |
| Filed products and full ingredients | China cosmetic filing records (NMPA), translated |
| Longer, thinner spicules open the skin more | Zhang et al., Pharmaceutics 2021. doi:10.3390/pharmaceutics13122119 |
| Blending breaks and shortens spicules | Tansathien et al., Biol Pharm Bull 2019. doi:10.1248/bpb.b19-00158 |
| ~850 channels per mm², closing over several days | Zhang et al., Biomater Sci 2019 (porcine skin, marine sponge spicules). doi:10.1039/c8bm01555d |
| Freshwater spicules can carry cosmetic actives | Kim et al., J Cosmet Dermatol 2022. doi:10.1111/jocd.14771 |
| Protocol, aftercare, activator, kit, actives, intensity | PEPTICEUTICAL labels and clinic protocol |
Published studies describe sponge spicules in general, not this product. PEPTICEUTICAL BIO-SPICULE is a topical cosmetic for professional use; it is not a drug or a device and is not intended to diagnose, treat or cure any disease. Results vary by skin type and protocol. Brand names belong to their owners. © 2026 Peptology Labs.
BIO-SPICULE V2
CLEAR · FIRM · GLOW · BRIGHT · MELA
Peptology Labs · Carmona, Cavite, Philippines
+63 949 702 6016 · peptology.ph